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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Sahaf B., Heydari K., Herzenberg L.A

Functional experiments confirmed that knocking down p21 expression in a DMM surgery-induced mouse OA model exacerbated articular cartilage degradation and was accompanied by a significant decrease in GPX4 protein levels in vivo , demonstrating that p21 plays an important anti-ferroptotic role in OA progression by modulating GPX4 stability (Zheng et al., 2024)

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[143] The film was released on September 13, 2019