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Constitutive MECP2 knockout (KO) mice, designed to study MECP2 loss, exhibit severe neurological symptoms such as uncoordinated gait, hindlimb clasping, and irregular breathing after an initial period of normal development (111, 112)

(2020) 367(6478):eaau6977

HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67

Corsini EM, Hofstetter WL, Group MD

Gelber to reclaim optimal mobility.

A total of 1740 movies were collected in a single session