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doi: 10.1016/j.plefa.2010.02.023
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Further clinical studies are necessary to evaluate long-term safety, efficacy across skin types, and formulation optimization
Research from the American Journal of Clinical Nutrition found that lipotropic amino acid combinations (methionine, inositol, choline) produce gastrointestinal side effects in approximately 18% of first-time users, typically resolving within 57 days as the body adjusts to elevated methionine metabolism
[DOI] [PubMed] [Google Scholar] Hull E
10.1007/s004410051181
