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594 Transferrin, high mobility group protein 1 (HMGB1), and CP are ferroptosis-related factors associated with PD in the substantia nigra

Schneider, S

[DOI] [PubMed] [Google Scholar] 20.Cuzzocrea S, Mazzon E, Dugo L, et al

This is where glutathione's role becomes significant

NADPH-dependent disulfide reductases Although there are hundreds of different NADPH-dependent enzymes in biology, each of which has the ability to use electrons extracted from NADPH to reduce specific organic or inorganic substrates, only two small groups of these enzymes, the Trx-disulfide reductases (TrxRs) and the glutathione-disulfide (GSSG)-reductases (Gsrs), can reduce an intracellular disulfide [42]

doi: 10.1038/ki.2014.359 27 SummersDMJohnsonRJHudsonACollettDWatsonCJBradleyJA