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doi: 10.1097/01.asn.0000077404.45564.7e

What DBS does well Reduces off time and motor fluctuations Reduces levodopa-induced dyskinesias (often via the medication reduction permitted by improved control) Reduces tremor and rigidity, particularly with STN stimulation Approved and available in dozens of countries, including the US, UK, EU, Japan, Australia, and most APAC markets What DBS does not do Does not regenerate dopamine neurons Does not slow the underlying neurodegeneration Limited effect on axial symptoms such as gait freezing, postural instability, speech, and cognitive symptoms Carries surgical risks (haemorrhage, infection, device-related complications) and lifelong follow-up requirements Where DBS sits relative to Amchepry Both DBS and Amchepry involve stereotactic neurosurgery and general anaesthesia

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Despite the advancements in immunotherapy, challenges such as the presence of cold tumours and treatment resistance persist

They can trigger immune responses, leading to inflammation and the activation of various immune cells such as macrophages, neutrophils, and lymphocytes

theyre one piece of a bigger puzzle we can influence with targeted nutrition, lifestyle, and (when appropriate) supplements