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The liver can extensively metabolize the drug before it passes into the hepatic vein and enters the systemic circulation

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[ 419 ] Idiopathic Pulmonary fibrosis (IPF) is a chronic and advancing disease featuring diffuse inflammation, interstitial fibrosis, and the distortion of the lung framework, resulting in extensive impairment and dysfunction of the lungs

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doi: 10.1182/blood.V126.23.2566.2566 49 GuerraVABurgerJABorthakurGMJabbourEPemmarajuNKadiaTMet al

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