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Deamidated tirzepatide has reduced receptor binding affinity, which directly translates to reduced therapeutic effect
Metformin, a drug used to treat type 2 diabetes, can also decrease absorption of B12 in the small intestine of 10 percent to 30 percent of patients
The compounded version Optimal Balance Pharmacy dispenses is co-formulated with cyanocobalamin (B12), which is pharmacologically inert with respect to weight loss
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