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Notably, the administration of Trolox effectively mitigated BLM-induced lipid peroxidation and attenuated the progression of PF [59]

Additionally, copper overload may trigger the opening of the mitochondrial permeability transition pore and cause the release of pro-apoptotic factors, ultimately resulting in cell death [135]

There is also some evidence that N- acetylcysteine reduces mortality in paracetamol induced liver failure, although the drug acts via a different mechanism from glutathione repletion [813]

92 , 42J49J (2003)

Kimberly Edwards and Kexiang Xu for help with the animal injections

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