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I cover more on this phenomenon in my folate article

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Circumstantial evidence for this hypothesis comes from one cohort study in which the combination of low B12 and high folate status was associated with lower serum holotranscobalamin concentrations than when B12 was low but folate was not elevated (81)

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To enable the volumes to be raised, the tip of the Jano needle must always enter and exit the subcutaneous tissue in the superficial part of the angle of dissection