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A study found that elevated inflammatory factors such as IL-6 and IL-8 in human bronchial epithelial cells exposed to CSE activated downstream signal transducer and activator of transcription 3 (STAT3) (186), which up-regulated the expression of lncRNA HOTAIR and enhancer of zeste homologue 2 (EZH2) (187)

Nano-formulations are capable of efficiently integrating multiple imaging probes or contrast agents into a single system, thereby realizing a genuine multimodal imaging platform [195, 196]