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Description
The engine driving the ship: metabolic steering of cell proliferation and death

Ultra-performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) enables precise quantification of structurally diverse BA species (175, 176), facilitating detailed characterization of the bile acid-ome. The emerging field of reverse metabolomics further accelerates the discovery of novel bioactive BA derivatives, including previously unannotated microbial metabolites, directly detected in human-derived biospecimens (82)

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Cystathionine -lyase (an enzyme involved in the transsulfuration pathway) is induced by TMZ to increase the supply of Cys (175)

At 12 h, hepatic d-lactate is 13 % lower and GLO activity is 52 % lower following BSO, which is fully restored by the exogenous addition of GSH [76]

Ther Drug Monit 29(6):687710
