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Sorafenib [a small-molecule multi-kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFRs) rapidly accelerated fibrosarcoma (RAF) and other protein kinases] has been regarded as the standard of treatment for patients with advanced HCC since 2007 (Ogunwobi et al., 2019) making anti-HGF/c-Met a promising therapeutic target for HCC treatment

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Therefore, we examined whether ECM remodeling factors are also reduced by ENPP2 knock-down in A375SM cells

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