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These effects occurred without changes in food intake, indicating that the fat loss resulted from altered fat metabolism rather than reduced caloric consumption

However, some rare side effects of too much vitamin B12 can include: Headache Weakness Nausea Diarrhea Tingling sensations in the hands and feet Allergic reactions or skin rash (uncommon) When To Seek Medical Advice Risk of vitamin B12 deficiency: Groups at a higher risk of vitamin B12 deficiency include older adults, people who only eat plant-based foods (vegans and vegetarians), and those with certain chronic conditions (gastrointestinal disorders that can affect vitamin absorption)

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Tesofensine also increased blood pressure, heart rate, and frequency of mood changes

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