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With persistent hypoxia, HIF-1 remains activated and drives abnormal expression of downstream genes, including heme oxygenase-1 ( H O -1 ) (Zhai et al., 2023)

The degradation that occurred during the warm period is permanent

Given that glutathione concentration can clearly increase in response to decreases in GSH:GSSG, it is unclear why the GSH:GSSG ratio does not seem to increase to compensate for decreases in glutathione concentration

Kyung, E

FAK mediates cell-matrix rearrangement by transmitting signals to MMPs, which play important roles in cell migration [9, 64, 65]

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