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[7] and requires vitamin C, vitamin B 6 , niacin, and reduced iron as cofactors [8]

Low-quality evidence from another trial that compared the effect of ALCAR (1.5 g/day) with that of methylcobalamin (1.5 mg/day) for 24 weeks suggested no difference between treatments regarding the extent of functional disability (using the Neuropathy Disability Scale) or measures of symptom quality and severity (using the Neuropathy Symptom Scale) (89)

Inhibition of transient receptor potential vanilloid type 1 through 2 adrenergic receptors at peripheral nerve terminals relieves pain

doi: 10.1046/j.1523-1755.1999.00273.x