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Finally, a study based on single-cell RNAseq has identified eight distinct T cell clusters, of which one uniquely present in SSc skin This CD4+ T cell subset is characterized by the expression of CXCL13 and IL-21 in addition to an T FH -like gene expression signature and that appears to be poised to promote B-cell responses within the inflamed skin of patients

Tamura J, Kubota K, Murakami H, et al

2020 Jul 25

Identification of a novel cis-element required for the constitutive activity and osmotic response of the rat aldose reductase promoter

Whatever the cause of the deficiency is, oral and injection supplements are considered safe and viable to treat the issue