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Recognized mechanisms include oxidative stress, mitochondrial dysfunction, neuroinflammation, insulin resistance, and protein misfolding

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Unlike eukaryotes and Gram-negative bacteria, where glutathione (GSH) is the primary thiol, in mycobacteria, GSH is absent and small molecules such as ET and mycothiol (MSH) constitute the major thiol reserve

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Administering glutathione intravenously ensures higher absorption rates compared to oral supplements, delivering the antioxidant directly into the bloodstream

3 Direct study of ROS ROS are highly reactive chemical entities that derive from molecular oxygen during metabolic reactions