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Individuals in the EXT-LC cohort were identified from The Winchester Centre for Lung Diseases Post-COVID-19 Recovery Program at Yale New Haven Hospital by collaborating clinicians

Elevated ferrous ions and iron homeostasis imbalances can further increase ROS through the Fenton reaction, also contributing to ferroptosis

In laboratory research models, GSH exerts its antioxidant activity through direct scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as through serving as an essential cofactor for glutathione peroxidase (GPx) enzymes, which catalyse the reduction of hydrogen peroxide and lipid hydroperoxides to non-toxic products