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Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-Review
The Mn 2+ form is found in dietary sources, is the most abundant form in circulation and is typically found complexed with various molecules, including albumin (which accounts for 84% of total Mn 2+ ), hexahydrated ions (6%), bicarbonate (6%), citrate (2%), and transferrin (1%)

doi: 10.1016/j.fct.2023.113624

Curcumin, a natural polyphenolic metabolites, has been shown in a systematic review of the literature to significantly reduce oxidative stress and exhibit antioxidant effects through multiple biological pathways, including inhibition of reactive oxygen species generation, upregulation of antioxidant enzyme expression, and regulation of lipid metabolism-related gene expression

Elevation of COR may disrupt the negative feedback regulation within the HPA axis in the CON group (42)
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