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10.1016/s0925-4773(99)00066-0 76 MulvaneyJ

The people with SPMS treated with natalizumab in the phase 3 ASCEND in SPMS trial (NCT01416181) had a decrease in their Multiple Sclerosis Impact Scale mean psychological scores from 39.1 at baseline to 36.7 at week 96, 21 which, although it was nonsignificant, was disconnected from longitudinal PROM changes with a steady decline in EDSS scores and the T25-FW
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the synergy is plausible and clinically observed, but not yet formally proven

Identifying immune cell infiltration and effective diagnostic biomarkers in rheumatoid arthritis by bioinformatics analysis
However, a 2025 review noted only 3 RCTs, calling for larger trials (Nguyen et al., 2025)