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In principle, sphingomyelin can be hydrolyzed by different enzymes: neutral SMase, acidic SMase, and secreted forms of SMases [120]

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Furthermore, there is some evidence that Golgi apparatus participates in intracellular MLKL trafficking in necroptosis [148]

These kinases possess a modulatory capacity for cellular activities and might phosphorylate transcription regulators, or proteins overseeing gene modulation