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Importantly, the majority of sulforaphanes neuroprotective effects are mediated by NRF2, since the absence of NRF2 prevents sulforaphanes effects (Innamorato et al., 2008

2003, 284: R245-R258

These findings suggest that epigenetic inactivation and regulation of the GPx3 pathway may be critical in the development and progression of different types of cancers

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doi: 10.1073/pnas.92.24.11165

PC-knockdown metM-Wnt lung and PC-knockdown E0771 cells, as compared to their respective scramble controls, were more sensitive to in vitro GPX4 inhibition via RSL3 treatment (Fig