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Using in vivo and ex vivo ischemia-reperfusion models, ozone treatment was shown to reduce myocardial injury by regulating ferroptosis-related proteins and transcription factors, particularly enhancing Nrf2 nuclear translocation, thereby exerting cardioprotective effects ( 3.1.5 Mechanisms of ferroptosis in myocardial ischemia-reperfusion injury In pathological conditions such as myocardial ischemia-reperfusion injury, the Nrf2/Keap1 pathway becomes dysregulated, leading to the dissociation of Nrf2 from Keap1 and its subsequent translocation into the nucleus

Inflammatory Markers I recommend looking at your inflammatory markers : HsCRP: The ideal number is under 1

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These tests may include patient history, X-rays and MRIs to get background and images of your spine

There was a subsequent development of an alternative model, using controlled cortical impact (CCI) utilized in ferrets (Lighthall, 1988), pigs (Duhaime et al., 2000