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KEAP1 cysteine oxidation then stabilizes NRF2 to allow its nuclear translocation, but chronic infection dysregulates this pathway, permitting ROS accumulation

Cell Mol Neurobiol 26 : 365384

[DOI] [PubMed] [Google Scholar] 119.Tang, D

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Although both cabozantinib and regorafenib have antiangiogenic properties via VEGFR2 and TIE2 inhibition and share similar kinase target profiles, regorafenib does not inhibit MET, which could explain the observed differences in treatment effects of cabozantinib and regorafenib in CRC cells