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GadA and GadB enzymes share 50.43% amino acid sequence identity (data not shown)

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With this perspective, Daughaday et al.[5, 42] proposed the somatomedin hypothesis for the postnatal growth, where GH stimulated skeletal growth by stimulating liver production of IGF-I, which in turn promotes longitudinal bone growth in an endocrine manner

Of 12 rats in each group, MA: MORUS ALBA LEAVES EXTRACT, GPx: glutathione peroxidase, GR: glutathione reductase

This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent