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Juglanin downregulates the expression of NOX4, decreases SOD activity, and inhibites the caspase-1 axis activation, and reduces IL-1 and IL-18 production, ameliorating cellular damage and exerting anti-inflammatory and anti-oxidant physiological utility (Sul and Ra, 2021)

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B.AbaziaD

Co-enzyme Q 10 This lipid-soluble antioxidant has a potential effect in PD via inhibition of TGF-1 production, thereby reducing scar formation

Allow complete inflammatory response and clearance between sessions

Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure