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Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation

Its additional immune-modulating properties, through the induction of interleukin-6 (IL-6), add another layer to its homeostatic and neuroprotective profile

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In first presentation adolescent anorexia nervosa, do cognitive markers of underweight status change with weight gain following a refeeding intervention

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For people on vegetarian or vegan diets, up to 90% have a vitamin B12 deficiency: even those who take extra vitamins