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Because the drug suppresses cortisol levels for less than 12 hours, some literature has found that twice- daily dosing may be necessary to control clinical signs over the course of the day

doi: 10.1016/j.etap.2011.12.011

Andrs-Rodrguez L, Borrs X, Feliu-Soler A, Prez-Aranda A, Rozadilla-Sacanell A, Montero-Marin J, Maes M, Luciano JV (2019) Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): A randomized, controlled clinical trial

Role of ornithine as a proline precursor in healing wounds