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33 Connections with Alzheimers disease and other motor neuron diseases have also been made

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(2021a) demonstrated that Ubiquitin-specific protease 7 (USP7) promotes ubiquitination of P53, leading to increased transcription of TfR1 and ferroptosis (Tang et al., 2021a)

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The short lifetime of singlet oxygen in aqueous solution (~4 s) allows diffusion over a distance up to ~200 nm

Using a small-molecule activator that disrupts the binding of Keap1 to Nrf2, KI696 (Davies et al., 2016), we first validated that treatment with KI696 could increase Nrf2 protein levels as well as increase expression of downstream target genes in KP cells (Figure 4figure supplement 1AC and Figure 4 1A)
