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Follow institutional protocols for reconstitution and aseptic handling
Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic Inhibitor G0/G1 switch gene 2 (G0S2)
The typical regimen involves: Loading dose for patients without neurological involvement : Hydroxocobalamin 1mg intramuscularly three times weekly for two weeks [13] [10] Loading dose for patients with neurological involvement : Hydroxocobalamin 1mg on alternate days until no further improvement, then Maintenance therapy : 1mg every two to three months (or every two months if neurological involvement) Lifelong maintenance therapy is necessary for irreversible causes such as pernicious anaemia or following gastric surgery
Many clinics offer numbing creams or ice to further minimize discomfort during the procedure
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Zelman DC, Brandenburg NA, Gore M
