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While SSRIs are efficacious, their safety profile in terms of reproductive system toxicity remains controversial, especially in developing adolescents, fertile adults, and perinatal pregnant women ( 2 Effects of SSRIs on reproductive cytogenesis 2.1 Effects of SSRIs on male germ cells Several studies have found that fluoxetine disrupts the hypothalamuslobetestis axis, significantly decreasing the serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone, and testosterone, while also affecting several sperm quality parameters, as evidenced by decreased sperm concentrations and viability, increased deoxyribonucleic acid (DNA) fragmentation, and lower reproductive organ weights (Figure 1), which could have been attributed to diminished androgen levels

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In the absence of ADP, mitochondrial O 2 consumption cannot be increased with Mg 2+ either

The key challenges involving microbial degradation of pesticides include the development of highly efficient pesticide-degrading GEMs, cultivation of microbial consortia and the quantitative research on pesticide biodegradation models

The computational pharmacokinetic profile of spinacetin showed it can be well absorbed by oral intake, without passing the blood brain barrier or becoming a P-glycoprotein substrate (Jose et al