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Particularly insightful mechanistic evidence comes from a medaka fish NAFLD model, where metabolomic analysis revealed that L-carnitine not only reduced hepatic lipid deposition but also significantly elevated hepatic -oxidation end products (acetyl-CoA and ATP) while upregulating antioxidant enzyme superoxide dismutase 2 (SOD2) (35)
Oxidative stress induces degradation of mitochondrial DNA
They have noted that the formulation has not only enhanced semen quality, it also improved sperm DNA integrity, fertilization rate, biochemical and clinical pregnancy rate, implantation rate, embryo quality as well as blastocyst development rate [88]
Mansour H
In the multiple regression analysis controlling for BMI value, gender, and age, this relationship was still significant ( t = 2.79, P = 0.007)
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