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Compared to Retatrutide, a triple agonist,

The receptor is part of the machinery through which a chronic lipolytic phenotype is expressed and its expression is upregulated by the peptide but the peptides acute lipolytic and thermogenic effects can proceed without it

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GLP-1 Receptor Activation: GLP-1 is a hormone that plays a key role in glucose metabolism

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10.1155/2012/302875 155 WuC.OrozcoC.BoyerJ.LegliseM.GoodaleJ.BatalovS.et al (2009)