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Author Contributions Conceptualization: C.L.P., A.D.G

doi: 10.1007/s00018-018-2815-y

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9 Systemic complications of KD The initial stage of KD is often accompanied by short-lived symptoms, commonly referred to as keto flu, including fatigue, gastrointestinal disturbances, and headache, which usually resolve within a few days (228, 229)

239 , 240 Nevertheless, generation and refinement of novel polygenic mouse models is important since complex genetics seems to contribute significantly to the pathogenesis of the human disease 241 Moreover, diverse genetic tools such as the generation of Chromosome Substitution Strains (CSSs) and combination of classical breeding approaches with high-throughput genotyping, sequencing and genetic engineering technologies, and information repositories highlight the power of the mouse for genetic, functional, and systems studies of complex traits and disease models

I remember attending a conference in 2013 and speaking to an endocrinologist about the intestinal permeability and thyroid connection, but he hadnt seen any of the research published in the endocrinology medical journals