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The same paper examines a few treatments

In vitro, 5-Amino-1MQ at 30 M in 3T3-L1 adipocytes significantly reduced intracellular 1-MNA levels, confirming NNMT target engagement

Patients should be advised about the urine discoloration (to avoid alarm) and counseled to report any persistent side effects

I do wish b12 vials were available in differing doses as maybe more often but less would work better

Greater focus and mental acuity
