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The foundation has to be in place for the targeted interventions to do their best work
The megaloblastic changes result from an interference with normal DNA synthesis, arising from lack of 5,10methylene tetrahydrofolate, as described for folate deficiency
( Heffereman et
It is needed for: Methylation B12 is cofactor in the process that synthesises the nearly universal methyldonor in the body: S-adenosyl-methionine
doi:10.1186/1472-6815-2-3
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