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Molecular characterization of GBM and diagnostic biomarkers Clinical grading of GBM GBM is classified as a World Health Organization (WHO) grade IV glioma, distinguished by aggressive behavior, high recurrence rates, and resistance to conventional therapies

Generally, the performance of ISGs is estimated using sol-gel transition temperature/time or titration tests

For example, hepatocyte growth factor (HGF) produced by tumor-associated fibroblasts (CAFs) and macrophages (TAMs) activates survival pathways, reinforcing temporary drug-tolerance (Heynen et al., 2014