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Uristegui-Acosta M, et al

Translational studies using exosomes showed a relationship between the epigenetic modulation of glutamatergic function and a brain metabolic dysfunction known as insulin resistance (IR) as showed by an increase and sex-specific phosphorylation in the expression of IRS1, a key marker of the insulin signaling cascade, in discrete exosomes enriched for the neural cell adhesion molecule L1 (L1CAM), a protein highly expressed in the brain [52, 70,71,72]

and GANAPATHY, V

The differences in the metabolism of these ACs may potentially become important biomarkers for distinguishing depression and schizophrenia, but these possibilities are yet to be explored in further research (Table 5)

Research indicates that FOXO1 can bind directly to the glycogen synthase genes promoter, thereby activating glucose production

Animal models could be of help in better understanding the molecular basis of MVP, possibly providing sufficient information to tackle specific mechanisms aimed at slowing down MVP progression, therefore developing non-surgical therapies impacting on the natural history of this condition