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Current clinical trials show AOD9604 has a good safety profile

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Notably, NNMT inhibition did not impact food intake in the DIO mice nor produce any overt signs of toxicity or adverse behavioral effects at the pharmacologically effective dose

[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Shetty S, Kusminski CM, Scherer PE

Finally, the relative abundance of sequences that could not be assigned to a defined genus was significantly higher in vehicle- and 5A-1MQ-treated mice switched from WD to LD relative to the WD control group (the former before FDR correction only