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Accumulation of these metabolites and their breakdown products in patients with CKD may be associated with the development of neurotoxicity and uremic breath. 481,487,492

Regardless of dosage, duration, or particular form (e.g., creatine monohydrate), oral creatine supplementation was used in all included investigations

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Hsieh, C

Journal of Cosmetic Dermatology (2020)