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The alternative pathway, also known as the bypass pathway, directly activates C3 by microorganisms or foreign bodies and is not dependent on antibodies

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[DOI] [PubMed] [Google Scholar] Pine, Jason

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Modulating mitochondrial quality control Mitophagy inducers By activating the AMPK, metformin instigates a signaling cascade that culminates in the phosphorylation of ULK1, thereby facilitating mitophagy [26]