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The polyunsaturated nature of PUFAs enables critical signaling and membrane fluidity functions while conferring peroxidation susceptibility, rendering membranes rich in PUFA-phospholipids-synthesized by ACSL4 and LPCAT3-vulnerable to ferroptosis through iron-catalyzed Fenton reaction-mediated oxidation (116)
In that study, GSTP1 overexpression was found to attenuate oxidative stress and ER stress as well as prevent rotenone-induced neurotoxicity
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These secondary metabolites which primarily produced by some spp
