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The mitochondrion is the one room where the two worlds meet

After SAM donates a methyl group, it becomes S-adenosylhomocysteine (SAH)

Conversely, the extrinsic pathway of apoptosis is initiated by the binding of death ligands to death receptors, which activates downstream effector caspase-8, ultimately resulting in the activation of caspase-3, -6, and 7, thereby inducing direct cell death [94]

(Epel et al., 2022)