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Among the DEGs listed, many encode hypothetical proteins (126 up regulated 66 down regulated)

39 Hippocampal atrophy in schizophrenia has been linked to neuronal atrophy and loss of neuropil, 74 which may be a consequence of redox dysregulation, although other factors such as inflammation and hypothalamicpituitaryadrenal axis dysfunction have also been shown to be important for hippocampus integrity

10.1016/j.exger.2022.111889 42 HanS.WuH.LiW.GaoP

doi: 10.1212/WNL.0000000000007371 29

As an endogenous vasodilator, NO plays a crucial role in regulating vascular morphology and reducing ROS production 27

Elevated circulating TMAO levels resulted in endothelial dysfunction in elderly rats, which was reversed by DMB treatment for 8 weeks (Li et al., 2017)