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Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes

NPCs, Neural Progenitor Cells

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R.LippardS

In patients with CP/CPPS (particularly NIH types III and IV), clinical studies based on 16S rRNA and metagenomic sequencing have confirmed that the homeostasis of the genitourinary microecosystem is disrupted, presenting a characteristic pattern of depletion of protective flora and enrichment of pathogenic flora. Specifically, in patient semen or prostatic fluid samples, the abundance of Lactobacillus species, which possess probiotic and anti-inflammatory properties, is significantly decreased, while the abundance of opportunistic pathogens represented by the phylum Proteobacteria (e.g., Pseudomonas, Escherichia) and Streptococcus is significantly increased (176, 177)