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There are also reports that rupture of the respiratory or intestinal epithelial barrier and weakening of other barriers, for example, the bloodbrain barrier or the vascular endothelial barrier, may facilitate the development of metabolic and autoimmune diseases [55, 81,82,83,84]

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The loss of IF can be caused by neutralizing antibodies to IF or autoimmune gastritis, which destroys the parietal cells that produce IF [53]

Protective mechanisms of simvastatin in experimental periodontal disease

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