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PMID: 1398722

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4, administration of C10:2 markedly upregulated PCNA, cyclinA, CDK2, Bcl-2, MMP2, MMP9, TGF-, while significantly dowregulated Caspase3 and Bax in PASMCs compared with PDGF-BB group, indicating that C10:2 may promote PASMCs proliferation, apoptosis inhibition and extracellular matrix remodeling in vitro

Studies in growth hormone-deficient mice show that while other growth hormone secretagogues increased body fat through growth hormone-independent mechanisms that included increased feeding, ipamorelin's effects on body composition are primarily mediated through its growth hormone-releasing properties

Regular physical activity is consistently linked to reduced epigenetic age acceleration, particularly in moderate-to-vigorous exercise cohorts [80]

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