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Description
Chronic Fatigue Syndrome A 2004 randomized trial demonstrated decreased fatigue severity and improved quality of life metrics in patients with chronic fatigue syndrome after 24 weeks of treatment at 2 grams daily [5][32]

Clin Chem Lab Med

Roddy D, McCarthy P, Nerney D, et al
A higher HRV indicates a more resilient and adaptable nervous system, capable of calming the hyperadrenergic state that drives the severe tachycardia and palpitations experienced by POTS patients

ALCAR transport decreases acetyl-CoA inside the mitochondria, but increases it outside

These findings implied that LC supplementation was not able to increase fat oxidation and improve exercise performance by the proposed mechanism