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confirmed that nicotine exposure, a key product of cigarettes, triggered oxidative stress in pancreatic stellate cells via induction of the mitochondrial dynamics towards fission as shown by upregulation of Drp1 and smaller, fragmented-shaped mitochondria

In colorectal cancer(CRC) research, gut microbiota-derived glutathione S-transferase 4 (Gsta4), a specific detoxifying enzyme for 4-hydroxynonenal (4-HNE), protects macrophages from ferroptosis