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The peptide did not produce adverse metabolic effects associated with full-length growth hormone, including insulin resistance, glucose intolerance, or IGF-1 elevation

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12 , 13 Moderate physical activity and healthy diets promote a balanced microbiome (eg, a high Bacteroidetes to Firmicutes ratio) along with the production of neurotransmitters (eg, serotonin, dopamine), secondary bile acids, and short-chain fatty acids, including acetate, propionate, and butyrate (Figure 1)

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